Abstract:
The Indonesian industrial sector has experienced very rapid development in the last 1 year with the use of dyes that are often used, namely congo red. Congo red producesaromatic compounds that can cause oxidative stress conditions that disrupt many organs such as the kidneys. However, the effects of this dye on the kidneys have not been widely studied. This study aims to analyze the effects of subchronic exposure to congo red on changes in serum creatinine levels. This study is an experimental study using 28 white Wistar rats. The white rats were divided into 4 groups, namely the control group, group P1, group P2, and group P3 equivalent to doses of 0, 190, 375, and 750 mg/kgBW. The duration of exposure to congo red in this study was 91 days. Analysis of creatinine levels in white rats was processed using the one-way ANOVA statistical test. The results of this study showed that the average creatinine levels were almost the same in each group. Statistical analysis showed a P value> 0.05 for creatinine levels in white rats. It was concluded that oral exposure to Congo Red in the subchronic period at doses of 190, 375, and 750 mg/kgBW did not reduce kidney filtration function, the normal average creatinine levels of white mice could be caused by the absence of sufficient damage to interfere with the kidneys in excreting blood creatinine related to the toxic effects of subchronic exposure to Congo Red.
